According to the Centers for Disease Control and Prevention, an estimated 1.6 million to 3.8 million concussions occur in the United States each year. Of those, 65 percent are estimated to occur in the pediatric and adolescent population. Although concussions dominate the sports literature, half of those occurring in the 11- to 15-year-old population are not sports-related. Therefore, concussions in children are not just a sports injury; they are a major pediatric public health problem.
CIRP, in collaboration with CHOP's Sports Medicine and Performance Center, is building a broad portfolio of concussion research to advance the field’s understanding of child and youth concussion and to fill in gaps in knowledge that hinder development of better prevention and treatment strategies. Specifically, we focus on rigorously describing concussion across the pediatric age range and clinical settings, providing data and methods to develop engineering and behavioral prevention strategies, improving diagnostic tools and how we manage recovery. With this information the field can advance targeted interventions to prevent concussion and optimize treatment to accelerate recovery.
Areas of Concussion Research at CIRP:
- Improving Pediatric Concussion Management
- Objective Measures for Concussion
- Institute of Medicine on Sports-related Youth Concussion
- More about Youth Concussion Research
- Characteristics of Concussion in Youth— This line of concussion research seeks to capture and describe the diversity and variability of the pediatric concussion patient population at CHOP and more broadly. By doing so, clinicians will be better equipped to recognize and treat specific concussion symptoms as well as predict recovery outcomes.
- Concussion Assessment Research Education (CARE) Consortium Longitudinal Clinical Study— This is a multi-site concussion consortium in which varsity athletes at participating colleges are assessed at baseline (pre-season) and then if they sustain a concussion, followed longitudinally through their recovery. CHOP serves as a CARE study site in collaboration with the University of Pennsylvania (Penn). As of September 2016: CHOP is enrolling and conducting baseline assessments on approximately 1,000 Penn varsity student-athletes over the course of the academic year. Those who experience concussion(s) will complete immediate post-concussion and follow-up assessments. Funding: NCAA-U.S. Department of Defense Grand Alliance
- Concussion Recovery App: Use of Ecologic Momentary Assessment to Track Symptoms-- With this concussion research study, researchers and clinicians tested the feasibility of using Ecologic Momentary Assessment (EMA) to help patients and clinicians assess cognitive and physical activity as well as concussion symptoms in real-time during recovery after pediatric concussion.
- Concussion Registry Development–- The initial objective of this concussion research is to test the feasibility of creating a comprehensive registry of patients 5-21 years old diagnosed with concussion within the CHOP Care Network. Data will capture how concussions are assessed, diagnosed, and treated. Tasks involve a review of the current data fields in CHOP’s electronic health records for capturing subject concussion information as well as data collection from patients presenting for new concussion evaluation. Patients are recruited from CHOP specialty care outpatient clinics, including sports medicine and orthopedics. By capturing a standardized and comprehensive data set on every child with concussion, we will form a valuable resource which can be utilized to answer other important questions about prevention, diagnosis and management of this common injury. Funding: Clinical and Translational Research Award (CTSA), The Children’s Hospital of Philadelphia Research Institute
- Genomic Markers for Concussion— Understanding what populations of children may be at increased risk for concussion, or may be more likely to have prolonged recovery, could allow for more targeted interventions that may help further reduce concussion incidence and severity. The primary aim of this project is to determine if variations in the human genome are associated with concussion incidence and/or outcomes-- specifically, the association between genomic variation and phenotypic outcomes in a cohort of patients prospectively identified with new concussion. In collaboration with CHOP’s Center for Applied Genomics (CAG) we are conducting a retrospective analysis on kids who have had genetic testing conducted as part of another study at CHOP and have a concussion diagnosis. We are also evaluating the feasibility and logistics of prospectively collecting this genetic information at the time of concussion diagnosis. Funding: Clinical and Translational Research Award (CTSA), The Children’s Hospital of Philadelphia Research Institute
- HIT HEADS Trial of Dietary Supplements-- HIT HEADS stands for “Head Injury Treatment with Healthy and Advanced Dietary Supplements.” Clinician-researchers are working to increase therapeutic options for treating concussions. One line of inquiry concerns the potential role for dietary supplements. The HIT HEADS is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of dietary supplements in the treatment of sports-related Concussion. Funding: Dana Foundation
- Leveraging Electronic Health Records (EHR) for Concussion Surveillance — This project leverages the single, linked electronic health record (EHR) system at CHOP to expand traumatic brain injury (TBI) surveillance and research, with a focus on concussion, and to assess whether EHR-based initiatives can improve TBI management. The line of concussion research explores the points of healthcare entry and number of types of providers seen, as well as the characteristics of and outcomes for patients who experienced one vs. multiple concussions as well as those with other co-morbidities.Through an analysis of patients with concussion seen at CHOP, one study describes the diversity of pathways of clinical care for children diagnosed with a concussion. Read the study that shows the vast majority of concussed children and youth who have a primary care provider enter the healthcare system through primary care. Additionally, one-third are under age 12 years. (View an infographic about this study)
Additionally, this project will use EHR, as well as surveys of CHOP providers, to evaluate the impact of implementing a standardized concussion management program that used EHR diagnostic and management support tools. Barriers and facilitators to use of these tools will be determined using survey methods. An important outcome measure for this study is how such a standardized system can facilitate the timely and accurate provision of return to learn/play instructions. Funding: Centers for Disease Control and Prevention
- Minds Matter: Concussion Care at CHOP–- This program was a two-year initiative to develop and refine a state-of-the-science standardized pediatric concussion management program across all CHOP departments that diagnose triage and treat concussion. These include primary care, sports medicine, emergency medicine, neurology, trauma and afterhours triage call center. Impact evaluation is underway leveraging CHOP’s EHR and provider surveys. Funding: Department of Pediatrics Chair's Initiatives, The Children's Hospital of Philadelphia
- Helmet-Based Kinematic Measurement Systems-- This concussion research is currently focused on evaluating the accuracy of sensor systems designed to be implemented for helmeted and non-helmeted sports to measure the kinematics of head impact of athletes in real sports settings. Such sensors are key to research efforts to identify thresholds for injury-causing impacts across the pediatric age range and across a range of real world impact conditions. Funding: National Science Foundation, plus more
- Quantitative Assessments for Sports-Related Concussion-- This five-year project will integrate neuroscience, bioengineering and clinical protocols that will involve instrumenting athletes on the field, using animal models in the laboratory and in-depth clinical observation of patients with concussion with a goal to develop a suite of quantitative assessment tools to enhance accuracy of sports-related concussion diagnoses, with a focus on objective metrics of activity, balance, neurosensory processing including eye tracking, as well as measures of cerebral blood flow. These could provide better guidelines for estimating both recovery time after a concussion and when young athletes can safely return to play. Researchers will examine the role of factors such as repeated exposures and direction of head motion. In addition, they will also look at sex-specific data to see how prevention and diagnosis strategies need to be tailored differently for males and females. Funding: National Institute of Neurological Diseases and Stroke
On October 30, 2013, the Institute of Medicine (IOM) released a report, Sports-Related Concussions in Youth: Improving the Science, Changing the Culture, which reviews the state of the science on sports-related concussion in children and youth ages 5 to 21. CIRP’s Co-Director and Director of Engineering Kristy Arbogast, PhD was a member of the 17-person expert committee that reviewed the science and created the evidence-based recommendations to improve concussion prevention, diagnosis, and management.
CIRP Concussion experts frequently blog about latest developments on CIRP's Research in Action Blog. Read the youth concussion-related articles.