Thomas Seacrist joined CHOP's Center for Injury Research and Prevention (CIRP) in 2007 with the primary responsibility of overseeing pediatric volunteer biomechanics experiments. His current research includes understanding how the anatomical and developmental differences between children and adults affect their motion during motor vehicle crashes, evaluating the biofidelity of child crash test dummies and identifying potential improvements, and detecting differences in driving behavior between novice teen and experienced adult drivers using simulated driving assessments.

He has presented and published internationally at traffic safety and engineering venues. Seacrist also serves as director of CIRP's Injury Science Training Program, including overseeing CIRP's Injury Science Research Experiences for Undergraduates site.

Prior to his time at CIRP, Seacrist studied the biomechanics of human motion in children with cerebral palsy at the National Rehabilitation Hospital and performed mechanical testing on bioengineered cartilage equivalents in the Orthopedics Research Department at the Alfred I. duPont Hospital for Children.