Center for Injury Research and Prevention

Abnormal Maturation of the Resting-State Peak Alpha Frequency in Children with Autism Spectrum Disorder

TitleAbnormal Maturation of the Resting-State Peak Alpha Frequency in Children with Autism Spectrum Disorder
Publication TypeJournal Article
Year of Publication2019
AuthorsJ Edgar C, Dipiero M, McBride E, Green HL, Berman J, Ku M, Liu S, Blaskey L, Kuschner E, Airey M, Ross JL, Bloy L, Kim M, Koppers S, Gaetz W, Schultz RT, Roberts TPL
JournalHum Brain Mapp
Volume40
Issue11
Pagination3288-3298
Date Published08/2019
Type of Articlejournal
ISSN1097-0193
Abstract

Age-related changes in resting-state (RS) neural rhythms in typically developing children (TDC) but not children with autism spectrum disorder (ASD) suggest that RS measures may be of clinical use in ASD only for certain ages. The study examined this issue via assessing RS peak alpha frequency (PAF), a measure previous studies, have indicated as abnormal in ASD. RS magnetoencephalographic (MEG) data were obtained from 141 TDC (6.13-17.70 years) and 204 ASD (6.07-17.93 years). A source model with 15 regional sources projected the raw MEG surface data into brain source space. PAF was identified in each participant from the source showing the largest amplitude alpha activity (7-13 Hz). Given sex differences in PAF in TDC (females > males) and relatively few females in both groups, group comparisons were conducted examining only male TDC (N = 121) and ASD (N = 183). Regressions showed significant group slope differences, with an age-related increase in PAF in TDC (R  = 0.32) but not ASD (R  = 0.01). Analyses examining male children below or above 10-years-old (median split) indicated group effects only in the younger TDC (8.90 Hz) and ASD (9.84 Hz; Cohen's d = 1.05). In the older ASD, a higher nonverbal IQ was associated with a higher PAF. In the younger TDC, a faster speed of processing was associated with a higher PAF. PAF as a marker for ASD depends on age, with a RS alpha marker of more interest in younger versus older children with ASD. Associations between PAF and cognitive ability were also found to be age and group specific.

DOI10.1002/hbm.24598
Alternate JournalHum Brain Mapp
PubMed ID30977235
PubMed Central IDPMC6592733
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
5U54HD086984 / / Eunice Kennedy Shriver National Institute of Child Health and Human Development /
R21 MH098204 / MH / NIMH NIH HHS / United States
R01HD093776 / / Eunice Kennedy Shriver National Institute of Child Health and Human Development /
R01DC008871 / / National Institute of Mental Health /
R21 NS090192 / NS / NINDS NIH HHS / United States
NS090192 / / National Institute of Mental Health /
R01 MH107506 / MH / NIMH NIH HHS / United States
R21MH098204 / / National Institute of Mental Health /
U54 HD086984 / HD / NICHD NIH HHS / United States
R01 HD093776 / HD / NICHD NIH HHS / United States
R01MH107506 / / National Institute of Mental Health /