Supranuclear disturbances of ocular motility in Lytico-Bodig.

TitleSupranuclear disturbances of ocular motility in Lytico-Bodig.
Publication TypeJournal Article
Year of Publication1988
AuthorsLepore FE, Steele JC, Cox TA, Tillson G, Calne DB, Duvoisin RC, Lavine L, McDarby JV
JournalNeurology
Volume38
Issue12
Pagination1849-53
Date Published1988 Dec
ISSN0028-3878
KeywordsAged, Amyotrophic Lateral Sclerosis, Dementia, Eye Movements, Female, Fixation, Ocular, Humans, Male, Middle Aged, Nystagmus, Physiologic, Pacific Islands, Parkinson Disease, Reflex, Vestibulo-Ocular
Abstract

We found abnormal supranuclear ocular or lid motility in all of 37 patients with Lytico-Bodig (amyotrophic lateral sclerosis/parkinsonism-dementia complex). Twenty-one patients had pursuit paresis, 18 abnormal vestibulo-ocular reflex (VOR) cancellation, 15 abnormal convergence, 13 abnormal optokinetic nystagmus (OKN), 12 conjugate gaze limitation, nine nystagmus, nine saccadic paresis, and six abnormal fixation. Lid abnormalities included glabellar hyperreflexia in 21, involuntary levator inhibition in three, and blepharospasm in two. Earlier reports have indicated infrequent ocular disturbances in Lytico-Bodig, but we now find supranuclear eye and lid deficits are universal and sometimes very prominent.

Alternate JournalNeurology
PubMed ID3194062